PREreview by Yan Zhou
This manuscript provides a deep understanding of clinicopathological characteristics shown by NECs and suggests the requirement of simultaneous targeting of coexisting tumor populations as a therapeutic strategy.
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Question | Yes | Unsure | N/A | No |
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Are the findings novel? | 100% | 0% | 0% | 0% |
Are the results likely to lead to future research? | 100% | 0% | 0% | 0% |
Is sufficient detail provided to allow reproduction of the study? | 100% | 0% | 0% | 0% |
Are the methods and statistics appropriate for the analysis? | 100% | 0% | 0% | 0% |
Are the principal conclusions supported by the data and analysis? | 100% | 0% | 0% | 0% |
Does the manuscript discuss limitations? | 50% | 50% | 0% | 0% |
Have the authors adequately discussed ethical concerns? | 50% | 50% | 0% | 0% |
Does the manuscript include new data? | 100% | 0% | 0% | 0% |
Are the data used in the manuscript available? | 0% | 100% | 0% | 0% |
Is the code used in the manuscript available? | 0% | 100% | 0% | 0% |
Would you recommend this manuscript to others? | 100% | 0% | 0% | 0% |
Do you recommend this manuscript for peer review? | 100% | 0% | 0% | 0% |
This manuscript provides a deep understanding of clinicopathological characteristics shown by NECs and suggests the requirement of simultaneous targeting of coexisting tumor populations as a therapeutic strategy.
In this study, Cejas et al. attempt to address the similarities and differences between a variety of neuroendocrine carcinomas (NECs) which originate from diverse tissues such as the lung, prostate and skin. In particular, they focus on the chromatin landscapes of these tumours with an aim to…