Write a PREreview

Mechanistic Modeling of Periodontal PathogenFusobacterium nucleatum-Induced Epithelial Oncogenic Transformation in Carcinomas via Selected FadA-Lactate-Angiogenesis Pathway

by Timothy Windham, Cris Mantilla, and Jimena Garcia

Posted: March 13, 2025
Server: bioRxiv
DOI: 10.1101/2025.03.10.642351

Periodontal pathogens, commonly found in the normal oral flora, have been implicated in cancer progression, yet their metabolic influence remains underexplored. This study investigates the role ofFusobacterium nucleatumin tumorigenesis by modeling bacterial-induced inflammation and metabolic shifts. Using computational simulations, we analyze key enzymatic fluxes and their impact on cancer development. Our findings highlight significant lactate accumulation and subsequent VEGF upregulation, suggesting potential biomarkers for early detection and novel therapeutic targets.

You can write a PREreview of Mechanistic Modeling of Periodontal PathogenFusobacterium nucleatum-Induced Epithelial Oncogenic Transformation in Carcinomas via Selected FadA-Lactate-Angiogenesis Pathway. A PREreview is a review of a preprint and can vary from a few sentences to a lengthy report, similar to a journal-organized peer-review report.

Before you start

We will ask you to log in with your ORCID iD. If you don’t have an iD, you can create one.