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Female reproductive physiology is characterized by its unique complexity. Despite advancements in research tools and resources, improvements in women’s healthcare remain limited. This qualitative study focuses on the fundamuntal principles of hemodynamics of the female reproductive system. Using a quasi-experimental setting, we applied several biophysical laws within the broader framework of the second law of thermodynamics: entropy. Contrary to previous findings which focus on the ovary, our results suggest that the myometrium actually plays the main role in regulating cervical mucus secretion, endometrial growth and even ovarian function, positioning the uterus as the key component of menstrual cycle regulation. In the light of our findings, we suggest a new approach in the hierarchy of the hypothalamic-pituitary-gonadal axis and the development of a potential new drug.