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Intraoperative Ephedrine Use in Hip Arthroplasty: A Comparative Analysis of Spinal Anesthesia Combinations and Chronic Hypertensive Status

by Erika Bimbo-Szuhai, Mihai Octavian Botea, Harrie Toms John, Adela Bostan Danciu, Pirvan Titus Razvan, Mihaela Gabriela Bontea, Caius Salajan, Maria Viviana Rusu, Adrian Gheorghe Osiceanu, and Iulia Codruta Macovei

Posted: February 25, 2025
Server: Preprints.org
DOI: 10.20944/preprints202502.1944.v1

Background and Objectives: We have conducted a retrospective study on patients who underwent total hip arthroplasty. We analyzed spinal anesthesia hemodynamic effects for optimal spinal anesthesia-induced hypotension (SAIH) management. This study explored the perioperative factors related to spinal anesthesia-induced hypotension and the dose of Ephedrine used to ensure hemodynamic stability. Materials and methods: Every patient benefits from information regarding details of the surgery approach and possible intraoperative hemodynamic variations induced by spinal anesthesia (SA). Three hundred twenty-nine patients were included in this study. We compared two groups based on the type of SA: bupivacaine with morphine (group M) and bupivacaine with fentanyl (group F). Results: We observed that the amount of ephedrine dose used correlates with high blood pressure (HBP) in 19 % of cases and with age in 44,1%. Conclusion: Ephedrine use for hemodynamic stability is the key to ensuring safer and more effective perioperative care.

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