Write a PREreview

Plasma Lipidomic Profiles of Kidney, Breast, and Prostate Cancer Patients Differ from Healthy Controls

by Denise Wolrab, Robert Jirásko, Ondřej Peterka, Jakub Idkowiak, Michaela Chocholoušková, Zuzana Vaňková, Karel Hořejší, Ivana Brabcová, David Vrána, Hana Študentová, Bohuslav Melichar, and Michal Holčapek

Posted: July 22, 2021
Server: Research Square
DOI: 10.21203/rs.3.rs-734203/v1

Early cancer screening is one of the unmet needs in clinical medicine. The peripheral blood analysis is a preferred method for efficient population screening as blood collection is well embedded in clinical practice and minimally invasive for patients. Lipids are important biomolecules, and variations in lipid concentrations may reflect pathological disorders. The lipidomic profiling by ultrahigh-performance supercritical fluid chromatography hyphenated to mass spectrometry of human plasma for distinguishing samples obtained from breast, kidney, and prostate cancer patients and healthy controls is investigated. The mean sensitivity, specificity, and accuracy of the new lipidomic profiling approach were 85%, 95%, and 92% for kidney cancer; 91%, 97%, and 94% for breast cancer; and 87%, 95%, and 92% for prostate cancer. No association of statistical models with tumor stage is observed. The statistically most significant lipid species for differentiation of studied cancer types are CE 16:0, Cer 42:1, LPC 18:2, PC 36:2, PC 36:3, SM 32:1, and SM 41:1.

You can write a PREreview of Plasma Lipidomic Profiles of Kidney, Breast, and Prostate Cancer Patients Differ from Healthy Controls. A PREreview is a review of a preprint and can vary from a few sentences to a lengthy report, similar to a journal-organized peer-review report.

Before you start

We will ask you to log in with your ORCID iD. If you don’t have an iD, you can create one.