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Structured PREreview of Identification of Potential Hub Genes and Therapeutic Targets in Colorectal Cancer Using Integrated Bioinformatics Approaches

Published
DOI
10.5281/zenodo.14213028
License
CC BY 4.0
Does the introduction explain the objective of the research presented in the preprint?
Partly
Yes, the author outlined the study's objectives. However, additional information is needed to provide a clearer understanding for the reader, as the current explanation appears somewhat superficial.
Are the methods well-suited for this research?
Somewhat appropriate
The authors have explicitly elucidated the method employed in data processing and analysis. However, the criteria for selecting the data of participants from the dataset, the process and rationale behind choosing only 59 and 62 colorectal cancer patients, and healthy participants respectively is unclear.
Are the conclusions supported by the data?
Somewhat supported
The discussion and conclusion of the study are superficial and narrow, lacking a comprehensive argument or alignment with findings from other research. Furthermore, the authors have not addressed the strengths and limitations of the study, nor have they offered clear perspectives for future research.
Are the data presentations, including visualizations, well-suited to represent the data?
Somewhat appropriate and clear
The authors have attempted to present and visualize the data; however, the visualization methods used are unclear and difficult to comprehend. Additionally, the figures appear somewhat unstandardized and lack visibility.
How clearly do the authors discuss, explain, and interpret their findings and potential next steps for the research?
Somewhat clearly
Already provided.
Is the preprint likely to advance academic knowledge?
Highly likely
Yes, very well, particularly in identifying the potentially mutated genes in colorectal cancer (CRC) that could advance the development of specific therapies for CRC.
Would it benefit from language editing?
No
The author needs to revise minor errors including; ''............1.9 million new cases and 0.9 million deaths reported in 2020In India, colorectal cancer is more commonly found in men than in women'', ..........Illumina BeadArray are widely used in microarray studies (10) The integration of deep..........''
Would you recommend this preprint to others?
Yes, but it needs to be improved
Already provided.
Is it ready for attention from an editor, publisher or broader audience?
Yes, after minor changes
Already provided.

Competing interests

The author declares that they have no competing interests.